ANTI-INFLAMMATORY EFFECTS OF Graptophyllum pictum (L.) GRIFF EXTRACT IN PRECLINICAL RATS HIND-PAW EDEMA MODELS: A LITERATURE REVIEW
DOI:
https://doi.org/10.00000/37a33t66Keywords:
Graptophyllum pictum (L.) Griff, Daun Ungu, Paw Edema, Anti-inflammationAbstract
Graptophyllum pictum (L.) Griff or daun ungu is a common medical plant in Indonesia that possesses many promising medical properties, including anti-inflammation. This review aims to discuss the anti-inflammatory effects of Graptophyllum pictum (L.) Griff extract in preclinical hind-paw edema animal models. Through literature search and analyze based on keywords, PICO, inclusion, and exclusion criteria, a total of four studies were included in this review. As a result, ethanol extract of Graptophyllum pictum (L.) Griff shows anti-inflammatory effects significantly reducing the volume of edema and having high anti-inflammatory power by inhibition of the arachidonic inflammatory pathway. Therefore, these preclinical test studies confirmed the anti-inflammatory effects of Graptophyllum pictum (L.) Griff. However, further studies and human trials are required to confirm the efficacy and develop a standardized formula for Graptophyllum pictum (L.) Griff.
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